664969-54-4

N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propenyl)-1-piperazinecarbothioamide is a a 4-thioureido-benzenesulfonamide derivative and a Wnt/β-catenin signaling inhibitor. Wnt/β-catenin signaling is involved with embryogenesis and tissue homeostasis.

LF3 is a potent inhibitor of Wnt/β-catenin signaling th at suppresses cancer cells motilitycell-cycle progressionand the overexpression of Wnt target genes. LF3 is a potent and specific antagonist of the interaction between β-catenin and the transcription factor TCF4. LF3 blocks self-renewal of cancer stem cells.

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