Brand name
Povan (Parke-Davis).
General Description
Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .
Fire Hazard
Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.
Description
Pyrvinium is a tasteless, odorless, bright orange to black,
crystalline solid. It is insoluble in water or ether,
slightly soluble in chloroform, and soluble in
glacial acetic acid.
Definition
ChEBI: Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.
Biochem/physiol Actions
Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
storage
4°C, protect from light ,unstable in solution, ready to use.
