Chemical Properties
dark brown liquid with an unpleasant odour
Chemical Properties
The odor of 2-vinylpyridine can be
detected at exposure levels below 1 ppm (v/v). The unpleasant
odor can be tolerated at concentrations that can produce
acute symptoms and irritation. Special precautions should be
taken to avoid skin and eye contact, as well as inhalation of
the vapor.
Uses
2-Vinylpyridine is a pyridine deriviative used in the preparation of poly(2-vinylpyridine) via radical polymerization. 2-Vinylpyridine is used to improve effectiveness of protective polymer coatings o
n metals. 2-Vinylpyridine is an impurity of Betahistine (B324000).
Application
2-vinylpyridine is except being used for fourth pyrrole (butylbenzene pyrrole) latex of synthetic widespread use, and also synthetic etc. for other polymer modification, ion exchange resin, dyeing and printing auxiliary, medicament.
General Description
2-Vinylpyridine (2VP) is a water soluble pyridine derivative that can be used in the synthesis of poly(2-vinylpyridine) (P2VP) by anionic polymerization. It can be industrially prepared by treatment of 2-methylpyridine with an aqueous solution of formaldehyde in a temperature range of 150-200°C.
Flammability and Explosibility
Flammable
Synthesis
The 2-vinylpyridine is mainly prepared from 2-picoline and formaldehyde. The process for synthesizing the 2-vinylpyridine comprises 'two-step' and 'one-step' production processes, and comprises the steps of condensing 2-picoline and formaldehyde to produce hydroxyethyl pyritine; and dehydrating the hydroxyethyl pyritine at a certain temperature in the action of a catalyst to generate the 2-vinylpyridine. The 'one-step' production process is adopted, 2-vinylpyridine is further generated at a certain temperature under the action of an acid catalyst by adopting 2-picoline and formaldehyde as raw materials, the process flow is simple, and the yield is high.
Carcinogenicity
No definitive information on
carcinogenicity of the vinylpyridines was found. However,
when either 2-vinylpyridine or 4-vinylpyridine was injected
intraperitoneally into A/J mice (200 mmol/animal), there
was no significant increase in lung adenoma or any other
tumors. None was listed as a carcinogen by IARC,
OSHA, NTP, and ACGIH.
Purification Methods
Steam distil it, then dry it with MgSO4 and distil it in a vacuum. [Beilstein 20 H 256, 20 III/IV 2884, 20/6 V 211.]
