6485-79-6

Clear colorless liquid

Selective silylation of primary hydroxy groups in the presence of secondary alcohol.

The bulky isopropyl groups (vs. ethyl) allow for more selective reductions, e.g., beta-selective reduction of anomeric C-phenyl ketals, but do not diminish their activity (e.g. in the copper triflate catalyzed reductive etherification of trimethylsilyl ethers).

Very sterically-hindered silane. Used as a cation scavenger in the deprotection of peptides.