ChemicalBook CAS DataBase List 64058-48-6

64058-48-6

Name	Spectinomycin sulfate tetrahydrate
CAS	64058-48-6
EINECS(EC#)	613-422-0
Molecular Formula	C14H26N2O11S
MDL Number	MFCD29915599
Molecular Weight	430.43
MOL File	64058-48-6.mol

Chemical Properties

Melting point	~185° (dec)
alpha	D25 +17.0° (c = 1 in water)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Water (Slightly)
form	neat
pka	pKa1 7.00, pKa2 8.75(at 25℃)
color	White

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301+P312+P330

Hazard Information

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Parameter	C₀ (μg/mL)	AUC_0-∞ (μg?h/mL)	V_d (L/kg)	CL (L/h/kg)	MRT (h)	T_1/2α (h)	T_1/2β (h)	T_1/2γ (h)	f_e	CL_renal (L/h/kg)	E_ratio
Non atrioventricular analysis	44.3	16.8	0.756	0.602	0.757	/	/	/	0.553	0.359	1.00
Three-compartment model	37.8	15.7	0.747	0.649	1.11	/	0.237	0.754	19.5	/	/

Animal Model:	Arbor Acres plus broiler chicks (15-day-old)^[4]
Dosage:	20 mg/kg, 60 mg/kg, 100 mg/kg
Administration:	Intramuscular injection (chest muscles); 9 days
Result:	Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR). Resulted minor toxicity of 60 mg/kg.