63927-23-1

34784-04-8

63927-23-1

Example 2: An aqueous solution of potassium nitrate (1.78 g, 8.56 mmol) was slowly added dropwise to a solution of 5-bromoisoquinoline dissolved in 12 mL of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 3 hours before it was poured into ice water and neutralized with concentrated ammonium hydroxide solution. The resulting yellow precipitate was extracted by ethyl acetate (3 x 10 mL) and the combined organic layers were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-bromo-8-nitroisoquinoline in 96% yield using a hexane solution of 40% ethyl acetate as eluent.