Preparation
Synthesis of 1,4-cyclohexanedione: put diethyl succinylsuccinate into a flask, add a mixture of concentrated sulfuric acid, water and ethanol, reflux in oil solution for 5 days, cool, and neutralize to pH with ammonia water = 8; then extract 4 times with chloroform, and recover the chloroform to obtain the crude product; then the crude product is subjected to vacuum distillation, and the distillate is poured into cold petroleum ether, filtered, and air-dried to obtain 1,4-cyclohexanedi Ketone Products.
Pharmacology
The cyclohexanedione
(CHD) herbicides inhibit fatty acid synthesis
in plants by interfering with the activity of
the enzyme Acetyl-Coenzyme A Carboxylase (ACCase).
ACCase-inhibiting herbicides provide excellent control of
grass weeds in dicotyledonous and some grass crops. A
less-sensitive ACCase mediates the intrinsic resistance
of dicotyledonous plants to the AOPP and CHD herbicides
(34,35). Although grasses are target species of this
group of herbicides, not all are equally affected, and sensitivity
differences can occur between varieties or even
within a genus.
