634-36-6

WHITE TO DARK BEIGE POWDER

1,2,3-Trimethoxybenzene can be used for RSM-optimised slow pyrolysis of rice husk for bio-oil production.

ChEBI: A methoxybenzene that is benzene substituted by methoxy groups at positions 1, 2 and 3 respectively.

Aqueous sodium hydroxide (40%，150 ml) is added dropwise during3-4 hr to a stirred mixture of pyrogallol (42 g，0.33 mole)，sodiumhydrosulphite (10 g,0.057 mole)，dimethyl sulphate (146 ml，194.60 g,1.54 mole) kept at 18-22°. Ice (1 kg) is then added and the reactionmixture left overnight. The separated solid is filtered and washed withwater. It is crystallised from methanol as colourless prisms. Yield 37.5 g(66.9%). M.p. 46-47°.Some more product (4 g, 7.1 %) is obtained byextraction of the mother liquor with ether (lit. m.p.46-47°).

Sublime it under vacuum. [Beilstein 6 H 1081, 6 I 540, 6 II 1066, 6 III 6265, 6 IV 7329.]