ChemicalBook CAS DataBase List 626-67-5

626-67-5

Name	N-Methylpiperidine
CAS	626-67-5
EINECS(EC#)	210-959-9
Molecular Formula	C6H13N
MDL Number	MFCD00006491
Molecular Weight	99.17
MOL File	626-67-5.mol

Chemical Properties

Appearance	CLEAR COLOURLESS LIQUID
Melting point	-50 °C
Boiling point	106-107 °C (lit.)
density	0.817 g/mL at 20 °C(lit.)
vapor pressure	35.7hPa at 20℃
refractive index	n20/D 1.438
Fp	38 °F
storage temp.	−20°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Liquid
pka	10.08(at 25℃)
color	Clear colorless
PH	12 (100g/l, H2O, 20℃)
biological source	synthetic
explosive limit	1.1-9.9%(V)
Water Solubility	miscible
BRN	1073
Henry's Law Constant	2.4×10^-1 mol/(m³Pa) at 25℃, Abraham et al. (1994)
Dielectric constant	2.5899999999999999
InChI	1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
InChIKey	PAMIQIKDUOTOBW-UHFFFAOYSA-N
SMILES	CN1CCCCC1
LogP	1.15 at 25℃
CAS DataBase Reference	626-67-5(CAS DataBase Reference)
NIST Chemistry Reference	Piperidine, 1-methyl-(626-67-5)
EPA Substance Registry System	626-67-5(EPA Substance)

Safety Data

Symbol(GHS)	GHS02,GHS05,GHS06
Signal word	Danger
Hazard statements	H225-H302+H312-H314-H331-H412
Precautionary statements	P210-P273-P280-P303+P361+P353-P304+P340+P311-P305+P351+P338+P310
Hazard Codes	C,F,T
Risk Statements	R11:Highly Flammable. R34:Causes burns. R20/22:Harmful by inhalation and if swallowed . R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R67:Vapors may cause drowsiness and dizziness. R22:Harmful if swallowed. R10:Flammable. less more
Safety Statements	S7:Keep container tightly closed . S16:Keep away from sources of ignition-No smoking . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S9:Keep container in a well-ventilated place . S33:Take precautionary measures against static discharges . less more
RIDADR	UN 3286 3/PG 2
WGK Germany	3
RTECS	TN1225000
F	3-10
TSCA	Yes
REACH Registrations	Active
HazardClass	3
PackingGroup	II
HS Code	29333999
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Dermal Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B
Safety Profile	Poison by intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. less more
Toxicity	LD50 intraperitoneal in mouse: 400mg/kg less more

Raw materials And Preparation Products

Hazard Information

General Description

A colorless liquid with the odor of pepper. Density 0.816 g/cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Reactivity Profile

1-METHYLPIPERIDINE(626-67-5) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Air & Water Reactions

Highly flammable. Soluble in water.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Description

This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Reactant for: ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines ·One-pot synthesis of Z-cinnamic acids Reactant for synthesis of: ·Unsymmetrical ureas ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases

Flammability and Explosibility

Highlyflammable

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) for n-methylpiperidine is 8 μg/m3 based on an annual averaging time.

References

Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939)

Material Safety Data Sheet(MSDS)

Spectrum Detail

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