625471-18-3

1271240-70-0

625471-18-3

General procedure for the synthesis of (S)-1-Boc-3-aminopiperidine from the compound (CAS:1271240-70-0): the azido derivative 42a (6.77 g, 29.9 mmol) was mixed with Pd/C catalyst (150 mg) in ethanol (200 mL) and subjected to a hydrogenation reaction at atmospheric pressure overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration followed by evaporation of the solvent. The product 43a was obtained as a colorless liquid in 90% yield (5.39 g, 26.9 mmol) without further purification. The 1H NMR, 13C NMR and IR spectral data of the product were in agreement with those reported in the literature30 . High-resolution mass spectrometry (HRMS, ESI) analysis showed a calculated and measured value of 201.1598 for C10H21O2N2 ([M + H]+); the specific spin [α]D20 was +26.0 (c 0.308, EtOH).