6231-18-1

2402-78-0

67-56-1

6231-18-1

(1) In a 500 mL three-necked flask, 29.6 g (0.2 mol) of 2,6-dichloropyridine, 16 g (0.4 mol) of sodium hydroxide solid, and 200 mL of methanol were added sequentially. A reflux condensing unit was installed, magnetic stirring was turned on and heated to reflux. After maintaining the reflux reaction for 8 hours, the heating was stopped. Most of the methanol solvent was evaporated by rotary evaporator under reduced pressure. After the reaction solution was cooled to room temperature, it was diluted with 100 mL of water. Extraction and separation were carried out with dichloromethane (100 mL×1), and the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the dichloromethane was removed by spin distillation under reduced pressure to obtain the crude 2,6-dimethoxypyridine. Finally, the target fractions were collected by purification via decompression distillation to obtain the colorless and transparent liquid product 2,6-dimethoxypyridine in 94% yield.