ChemicalBook CAS DataBase List 57982-77-1

57982-77-1

Name	Buserelin
CAS	57982-77-1
EINECS(EC#)	261-061-9
Molecular Formula	C60H86N16O13
MDL Number	MFCD00870371
Molecular Weight	1239.42
MOL File	57982-77-1.mol

Synonyms

hoe766a receptal etilamide ici123215 BUSERELIN Buserilin Suprefact Buserelin CRS BUSERELIN PH. EUR. Buserelin, Buserelina (d-ser(tbu)(sup6)-ea(sup10))-lhrh d-ser-(tbu)(sup6)-lhrh-ethylamide (DES-GLY10,D-SER(TBU)6,PRO-NHET9)-LHRH PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET P-GLU-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET d-ser(tbu(sup6))-lh-rh-(1-9)-nonapeptideethylamide (d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt (d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon (d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone luteinizinghormone-releasinghormone(pig),6-(o-(1,1-dimethylethyl)-d-serine) 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)- (Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt BuserelinQ: What is Buserelin Q: What is the CAS Number of Buserelin Q: What is the storage condition of Buserelin Buserilin,1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)- (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2 (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Chemical Properties

Appearance	White or slightly yellowish powder, hygroscopic.
alpha	D20 -40.4° (c = 1 in dimethylacetamide)
Boiling point	845.19°C (rough estimate)
density	1.0711 (rough estimate)
refractive index	1.6200 (estimate)
solubility	Sparingly soluble in water and in dilute acids.
form	Solid
pka	9.82±0.15(Predicted)
color	White to Off-White
Stability:	Hygroscopic
Major Application	pharmaceutical (small molecule)
InChIKey	CUWODFFVMXJOKD-UHFFFAOYSA-N

Safety Data

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H360F
Precautionary statements	P308+P313
WGK Germany	WGK 3
HS Code	2937190000
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Repr. 1B

Hazard Information

Chemical Properties

White or slightly yellowish powder, hygroscopic.

Uses

Gonad-stimulating principle.

Brand name

Suprefact (Hoechst-Roussel).

Description

Buserelin (Suprefact?) is a hormonal therapy drug used to treat advanced prostate cancer. It is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.

Definition

ChEBI: Buserelin is an oligopeptide.

Clinical Use

Treatment of advanced prostate cancer and endometriosis

Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins

Side effects

Using too much Buserelin Injection may make you feel weak, nervous, dizzy and sick. You may also have a headache, hot flushes, stomach pain, swelling of the legs and breast pain. You may also have pain, bleeding or hardening of the skin at the site of injection

Drug interactions

Potentially hazardous interactions with other drugs
None known

Metabolism

Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.

Supplier

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