Chemical Properties
White or almost white powder.
Uses
Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
Uses
Osteoporosis;Hypercalcemia; Paget’s disease
; Reflex sympathetic dystrophy (algodistrophy or Sudeck’s disease)
Brand name
Calcimar (Rhone-
Poulenc Rorer);.
Biochem/physiol Actions
Calcitonin also refers as thyrocalcitonin is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compare to serum. It acts as a first messenger and hence regulate the the production of cAMP as well as mammalian sperm function. It may also facilitate the regulation of different isoforms of adenylyl cyclase. Additionally, salmon calcitonin stimulates the bone formation and inhibits the bone resorption in postmenopausal osteoporotic women.
Clinical Use
Only salmon CT is commercially available for medical use, because on a weight basis, it is
approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved
for treating Paget's disease of bone (generally seen in older persons; involves increased bone
resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy
(multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray
formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.
Veterinary Drugs and Treatments
In small animals, calcitonin has been used as adjunctive therapy to
control hypercalcemia.
Its use has been limited by expense, availability
and resistance development to its effects after several days
of treatment.
