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57-64-7

Name PHYSOSTIGMINE SALICYLATE
CAS 57-64-7
EINECS(EC#) 200-343-8
Molecular Formula C22H27N3O5
MDL Number MFCD00135659
Molecular Weight 413.47
MOL File 57-64-7.mol
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Chemical Properties

Appearance solid
Melting point  181-183 °C
storage temp.  -20°C
solubility  DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
form  neat
pka pKa 1.96/8.08(H2O,t =15) (Uncertain)
color  White to yellow
Usage Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
Merck  7384
BRN  3900576
InChIKey HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS DataBase Reference 57-64-7(CAS DataBase Reference)
EPA Substance Registry System Physostigmine salicylate (57-64-7)

Safety Data

Hazard Codes  T+
Risk Statements 
R26/28:Very Toxic by inhalation and if swallowed .
Safety Statements 
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  TJ2450000
HazardClass  6.1(a)
PackingGroup  II
HS Code  2939800000
Safety Profile
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.
Toxicity
LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

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