ChemicalBook CAS DataBase List 57-64-7

57-64-7

Name	PHYSOSTIGMINE SALICYLATE
CAS	57-64-7
EINECS(EC#)	200-343-8
Molecular Formula	C22H27N3O5
MDL Number	MFCD00135659
Molecular Weight	413.47
MOL File	57-64-7.mol

Synonyms

ESERINE MONOSALICYLATE ESERINE SALICYLATE ESERINE SALICYLATE SALT PHYSOSTIGMINE SALICYLATE PHYSOSTIGMINE SALICYLATE SALT 2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci ar-44 physostigmine,[salicylate(1:1)] physostigmine,salicylate(1:1) physostolsalicylate salicylicacid,compd.withphysostigmine(1:1) tl-1380 trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1) ESERINE SALICYLATE 99.9% Physostigmine monosalicylate Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1) PHYSOSTIGMINESALICYLATE,USP ESERINE SALICYLATE(RG) Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI) Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)

Chemical Properties

Appearance	solid
Melting point	181-183 °C
storage temp.	-20°C
solubility	DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
form	neat
pka	pKa 1.96/8.08(H2O,t =15) (Uncertain)
color	White to yellow
biological source	synthetic
Optical Rotation	[α]20/D -77±2°, c =1% in ethanol
Usage	Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
Merck	7384
BRN	3900576
InChIKey	HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES	C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O \|&1:8,13,r\|
CAS DataBase Reference	57-64-7(CAS DataBase Reference)
EPA Substance Registry System	Physostigmine salicylate (57-64-7)

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300+H330
Precautionary statements	P301+P310+P330-P304+P340+P310
Hazard Codes	T+
Risk Statements	R26/28:Very Toxic by inhalation and if swallowed . less more
Safety Statements	S25:Avoid contact with eyes . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 1544 6.1/PG 1
WGK Germany	3
RTECS	TJ2450000
TSCA	TSCA listed
HazardClass	6.1(a)
PackingGroup	II
HS Code	2939800000
Safety Profile	Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE. less more
Toxicity	LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) less more

Hazard Information

General Description

Crystal form that turns red on exposure to heat or light.

Reactivity Profile

Behaves as a weak acid in solution.

Health Hazard

This compound is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.

Fire Hazard

When heated to decomposition, PHYSOSTIGMINE, [SALICYLATE (1:1)] emits toxic fumes of nitrogen oxides.

Chemical Properties

solid

Uses

cholinergic, anticholinesterase, miotic

Uses

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Definition

ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.

Brand name

Antilirium (Forest); Isopto Eserine (Alcon).

Biological Activity

Acetylcholinesterase inhibitor th at crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase th at degrades slowly.

storage

-20°C

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Shanghai Leiming Medical Technology Co., LTD

Telephone 13761371720

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList170799/0_EN.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Syntechem Co.,Ltd

Telephone

Websitehttp://www.syntechem.com/

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Beijing Yisiyan Technology Research Center

Telephone010-56645598 13366904824;

Websitehttp://www.bjkaida.cn

UHN Shanghai Research & Development Co., Ltd.

Telephone021-58958002 18930822973

Websitehttp://www.uhnshanghai.com

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Finetech Industry Limited

Telephone027-87465837 19945049750

Websitehttps://www.finetechchem.com/

Shanghai Macklin Biochemical Co.,Ltd.

Telephone15221275939 15221275939

Websitehttp://www.macklin.cn

Chizhou Kailong Import and Export Trade Co., Ltd.

Telephone

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16778/0_EN.htm

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

1of4

Related Products

Send Inquriy