Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Material Safety Data Sheet(MSDS) Well-known Reagent Company Product Information
WebSite >  CAS DataBase List  > 57-57-8

57-57-8

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Material Safety Data Sheet(MSDS) Well-known Reagent Company Product Information

Product Image

Identification

Name
2-Oxetanone
CAS
57-57-8
Synonyms
2-OXETANONE
3-HYDROXYPROPIONIC ACID LACTONE
ALPHA-PROPIONOLIDE
BETA-HYDROXYPROPIONIC ACID LACTONE
BETA-PROPIOLACTONE
BETA-PROPIONOLACTONE
B-PROPIOLACTONE
HYDRACRYLIC ACID BETA-LACTONE
HYDRACRYLIC ACID LACTONE
OXETANONE-2
β-Propiolactone
1,3-Propiolactone
2-Oxacyclobutanone
2-Oxooxetane
3-hydroxy-propanoicacibeta-lactone
3-Hydroxypropionic acid beta-lactone
3-hydroxy-propionicacibeta-lactone
3-hydroxypropionicacid,beta-lactone
3-Propanolide
3-propanolyde
EINECS(EC#)
200-340-1
Molecular Formula
C3H4O2
MDL Number
MFCD00005169
Molecular Weight
72.06
MOL File
57-57-8.mol

Chemical Properties

Appearance
Colorless to light yellow liqui
Appearance
β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable.
mp 
−33 °C(lit.)

bp 
162 °C(lit.)

density 
1.146 g/mL at 25 °C(lit.)

refractive index 
n20/D 1.412(lit.)

Fp 
158 °F

storage temp. 
2-8°C
Water Solubility 
37 g/100 mL
Usage
Reacts with bacteriphage DNA causing inactivation, repair and recombination
Merck 
14,7820
CAS DataBase Reference
57-57-8(CAS DataBase Reference)
NIST Chemistry Reference
«beta»-Propiolactone(57-57-8)
Storage Precautions
Light sensitive;Store under argon gas
EPA Substance Registry System
57-57-8(EPA Substance)

Safety Data

Hazard Codes 
T+
Risk Statements 
R45:May cause cancer.
R26:Very Toxic by inhalation.
R36/38:Irritating to eyes and skin .
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 3382 6.1/PG 1

WGK Germany 
3

RTECS 
RQ7350000

HazardClass 
6.1
PackingGroup 
I
HS Code 
29322090
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazardous Substances Data
57-57-8(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.
Reactivity Profile
BETA-PROPIOLACTONE(57-57-8) is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical may be incompatible with alkalis.
Air & Water Reactions
Slow reaction with water to form beta-hydroxypropionic acid.
Hazard
Strong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.
Health Hazard
The toxicity potential of this material via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.
Potential Exposure
β-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Fire Hazard
Containers may explode. When heated to decomposition, BETA-PROPIOLACTONE emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.
Shipping
UN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Reacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Material Safety Data Sheet(MSDS)

msds information
2-Oxetanone(57-57-8).msds

Well-known Reagent Company Product Information

SupplierMore