ChemicalBook CAS DataBase List 54556-98-8

54556-98-8

Name	Propiverine hydrochloride
CAS	54556-98-8
Molecular Formula	C23H30ClNO3
MDL Number	MFCD01672343
Molecular Weight	403.94
MOL File	54556-98-8.mol

Chemical Properties

Appearance	Off-White Solid
Melting point	224-226°C
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL, clear (warmed)
form	powder
color	white to beige
Usage	Used in treatment of urinary incontinence
CAS DataBase Reference	54556-98-8(CAS DataBase Reference)

Safety Data

Hazard Codes	Xi
Risk Statements	37/38-41 less more
Safety Statements	26-39 less more
WGK Germany	3
RTECS	AH3297000
Toxicity	LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita) less more

Hazard Information

Description

Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.

Chemical Properties

Off-White Solid

Originator

Apogepha (Germany)

Uses

Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.

Definition

ChEBI: Propiverine hydrochloride is a diarylmethane.

Brand name

Mictonorm; Mictonetten

General Description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Clinical Use

Treatment of urinary frequency, urgency and incontinence
Neurogenic bladder instability

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine, bile and faeces.

Supplier

Kangmei Pharmaceutical Co., Ltd.

Telephone0663-2917777

Websitehttp://www.kangmei.com.cn

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

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J & K SCIENTIFIC LTD.

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Chemsky（shanghai）International Co.,Ltd.

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XiaoGan ShenYuan ChemPharm co,ltd

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Dalian Meilun Biotech Co., Ltd.

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Beijing Yisiyan Technology Research Center

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Beijing Lianben Pharm-Chemicals Tech. Co., Ltd

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TargetMol Chemicals Inc.

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ChemStrong Scientific Co.,Ltd

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Hangzhou J&H Chemical Co., Ltd.

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Credit Asia Chemical Co., Ltd.

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Hubei Jusheng Technology Co.,Ltd

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Websitehttp://www.jushengtech.com

Chizhou Kailong Import and Export Trade Co., Ltd.

Telephone

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Sigma-Aldrich

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Websitehttps://www.sigmaaldrich.cn

AN PharmaTech Co Ltd

Telephone86(21)68097365

Websitehttp://www.anpharma.net

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