50-22-6

Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.

white to light yellow powder

Corticosteroid is an activator of MCR.

Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.

ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan s.

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

IL Receptor | TNF-α | AChR

Room temperature

Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]

[1] NICK Z LU. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.[J]. Pharmacological Reviews, 2006, 58 4: 782-797. DOI: 10.1124/pr.58.4.9
[2] R PALME. Stress Hormones in Mammals and Birds: Comparative Aspects Regarding Metabolism, Excretion, and Noninvasive Measurement in Fecal Samples[J]. Annals of the New York Academy of Sciences, 2006, 1040 1: 162-171. DOI: 10.1196/annals.1327.021
[3] GOYMANN W, M?STL E, GWINNER E. Corticosterone Metabolites can be Measured Noninvasively in Excreta of European Stonechats (Saxicola torquata rubicola)[C]//13 1. 2002: 0. DOI: 10.1642/0004-8038(2002)119[1167:cmcbmn]2.0.co;2
[4] G. VáZQUEZ-PALACIOS. Further definition of the effect of corticosterone on the sleep–wake pattern in the male rat[J]. Pharmacology Biochemistry and Behavior, 2001, 70 2: Pages 305-310. DOI: 10.1016/s0091-3057(01)00620-7
[5] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.