ChemicalBook CAS DataBase List 4065-45-6

4065-45-6

Name	2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
CAS	4065-45-6
EINECS(EC#)	223-772-2
Molecular Formula	C14H12O6S
MDL Number	MFCD00024962
Molecular Weight	308.31
MOL File	4065-45-6.mol

Synonyms

2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid 2-HYDROXY-4-METHOXY-5-SULFOBENZOPHENONE 2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID HYDRATE 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID 5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID BENZOPHENONE-4 BP-4 HMBS spectra-sorb uv 284 SULISOBENZONE TIMTEC-BB SBB002961 UV ABSORBER HMBS Uvistat 1121 2-benzoyl-5-methoxy-1-phenol-4-sulfonicaci 2-Hydroxy-4-Methoxy-5-Benzophenonesulfonicacid 5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonicaci Benzenesulfonicacid,5-benzoyl-4-hydroxy-2-methoxy- Benzophenone-4,sulisobenzone

Chemical Properties

Appearance	white to yellowish powder
Melting point	170 °C
Boiling point	0°C
density	1.4574 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5300 (estimate)
Fp	0°C
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	neat
pka	-0.70±0.50(Predicted)
color	White to Off-White
Water Solubility	300.92g/L at 25℃
Merck	14,8983
BRN	2889165
Contact allergens	BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen. less more
InChIKey	CXVGEDCSTKKODG-UHFFFAOYSA-N
LogP	0.515 at 25℃
Uses	benzophenone-4 (sulisobenzone) is a commonly used, FDAapproved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. less more
CAS DataBase Reference	4065-45-6(CAS DataBase Reference)
EPA Substance Registry System	4065-45-6(EPA Substance)

Safety Data

Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . S37/39:Wear suitable gloves and eye/face protection . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S27:Take off immediately all contaminated clothing . less more
WGK Germany	1
RTECS	DB5044300
TSCA	Yes
HS Code	29144000
Hazardous Substances Data	4065-45-6(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Chemical Properties

white to yellowish powder

Uses

ultraviolet screen

Uses

Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.

Originator

Uval,Dome,US,1965

Definition

ChEBI: Sulisobenzone is a member of benzophenones.

Manufacturing Process

663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.

Brand name

Sungard (Bayer).

Therapeutic Function

Sunscreen agent

General Description

Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.

Flammability and Explosibility

Nonflammable

storage

Store at -20°C

Well-known Reagent Company Product Information

Supplier

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