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367-67-9

General procedure for the synthesis of 2-bromo-5-nitrobenzotrifluoride from o-bromobenzotrifluoride: 260 g of concentrated sulfuric acid (98%) was placed in a reaction flask at room temperature, and 120 g of fuming nitric acid was added slowly to prepare a nitrification acid mixture. The temperature of the reaction system was maintained at 50-60°C, and 390g of o-bromobenzotrifluoride was slowly added to the mixed acid. After the addition was completed, the temperature was maintained and the reaction continued to be stirred until the GC test showed that the raw material was completely consumed and the reaction was completed. After the reaction solution was left to stratify, the upper organic phase was separated and washed to neutrality with alkali. A bright yellow liquid was obtained, which was immediately post-treated to finally obtain 450.4 g of 2-bromo-5-nitrobenzotrifluoride, with a GC purity of 95% and a yield of 92%.