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Sulfadimethoxine, with the chemical formula C????H????N????O??S and a molecular weight of 278.33, typically appears as a white crystalline powder. First synthesized in the 1940s, it is a member of the sulfonamide antibiotic family. These antibiotics were first discovered by German chemist Gerhard Domagk in the late 1930s, and their discovery revolutionized medicine. As part of this family, sulfadimethoxine later became an important broad-spectrum antibiotic.

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.