Synthesis
Example 33: Synthesis of 1-trityl-1H-imidazole-4-carbaldehyde
4-Imidazolecarboxaldehyde (30.0 g, 0.30 mol) was dissolved in DMF (200 mL) and triethylamine (70 mL, 0.375 mol) was added slowly under cooling in an ice bath. Triphenylchloromethane (105 g, 0.375 mol) was then added in batches and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum evaporation and the residue was washed with anhydrous ether (4 x 50 mL) and dried to give a yellow solid 1-tritylimidazole-4-carboxaldehyde (100 g, 100%).
References
[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 23, p. 7993 - 8002
[2] Patent: WO2008/4096, 2008, A1. Location in patent: Page/Page column 79
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 1, p. 177 - 188
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 18, p. 3957 - 3962
[5] Patent: US2004/122018, 2004, A1. Location in patent: Page 317
