ChemicalBook CAS DataBase List 18156-74-6

18156-74-6

Name	N-(Trimethylsilyl)imidazole
CAS	18156-74-6
EINECS(EC#)	242-040-3
Molecular Formula	C6H12N2Si
MDL Number	MFCD00005280
Molecular Weight	140.26
MOL File	18156-74-6.mol

Chemical Properties

Appearance	Colorless transparent liquid
Melting point	-42 °C
Boiling point	93-94 °C14 mm Hg(lit.)
density	0.957 g/mL at 20 °C
refractive index	n20/D 1.475(lit.)
Fp	42 °F
storage temp.	2-8°C
solubility	Chloroform
form	Liquid
pka	7.96±0.10(Predicted)
color	Clear colorless to yellow
Specific Gravity	0.956
Water Solubility	decomposes
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
Sensitive	Moisture Sensitive
Detection Methods	NMR
BRN	606148
Stability:	Air and Moisture Sensitive
InChIKey	YKFRUJSEPGHZFJ-UHFFFAOYSA-N
CAS DataBase Reference	18156-74-6(CAS DataBase Reference)
NIST Chemistry Reference	1h-Imidazole, 1-(trimethylsilyl)-(18156-74-6)
Storage Precautions	Store under nitrogen;Light sensitive;Moisture sensitive
EPA Substance Registry System	18156-74-6(EPA Substance)

Safety Data

Hazard Codes	F,Xi
Risk Statements	R11:Highly Flammable. R36/37/38:Irritating to eyes, respiratory system and skin . R14:Reacts violently with water. less more
Safety Statements	S16:Keep away from sources of ignition-No smoking . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S33:Take precautionary measures against static discharges . S37/39:Wear suitable gloves and eye/face protection . less more
RIDADR	UN 1993 3/PG 2
WGK Germany	3
RTECS	NI8700000
F	10-21
Autoignition Temperature	540 °C DIN 51794
TSCA	T
HazardClass	3
PackingGroup	II
HS Code	29332990

Hazard Information

Chemical Properties

Colorless transparent liquid

Physical properties

bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3.

Uses

A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives.

Uses

N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency.

Uses

N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses.

Uses

Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1

Definition

ChEBI: A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications.

General Description

1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Taizhou Hiri Chemical Inc.

Telephone 15168669309

Website

TCI (Shanghai) Development Co., Ltd.

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Hubei xinghengkang Chemical Technology Co., Ltd

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Henan Jiuke Chemical Co. LTD

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Shanghai Song Yuan Chemical Technology Co., Ltd.

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Beijing Jinrui Meixiang Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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Websitehttp://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

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Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

BeiJing Hwrk Chemicals Limted

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Websitehttp://www.hwrkchemical.com

Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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Accela ChemBio Co.,Ltd.

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Shanghai Longsheng chemical Co.,Ltd.

Telephone021-58099652-8005 13585536065

Websitehttp://www.shlschem.com

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070

Websitehttp://www.echemlin.cn

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