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  Step 1, Synthesis of 2-(3-bromophenyl)acetamide

  Under a nitrogen atmosphere, 1-hydroxybenzotriazole (HOBT, 13.82 g, 102.3 mmol), N-ethyldiisopropylamine (13.22 g, 102.3 mmol), and ammonium carbonate (27.0 g, 279.0 mmol) were added to 3-bromophenylacetic acid (20.0 g, 93.0 mmol) in a freshly dried and distilled solution of tetrahydrofuran (80 mL). The reaction mixture was stirred at room temperature for about 5 minutes, then cooled to 0°C and stirred at the same temperature for about 1 hour.

  1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI.HCl, 19.61 g, 102.3 mmol) was added at 0 °C under a nitrogen atmosphere. The reaction mixture was stirred at room temperature for about 12 hours. The solvent was evaporated under vacuum and water was added to give a white solid, which was filtered, washed with water, and dried to give 2-(3-bromophenyl)acetamide, yield 12.69 g.

  Step 2, Synthesis of 3-bromobenzyl cyanide

  2-(3-bromophenyl)acetamide (10.0 g, 46.73 mmol) in dry 1,4-dioxane (100 mL) was cooled to 0 °C, and triethylamine (18.91 g, 187.92 mmol) was added. The reaction mixture was stirred for about 10 minutes. Trifluoroacetic anhydride (39.26 g, 186.92 mmol) was added dropwise at 0 °C, and the reaction mixture was stirred at room temperature for about 12 hours. The reaction mixture was poured into cold water, extracted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate, filtered, and the solvent was evaporated under vacuum to give an oily residue. This residue was purified by silica gel column chromatography, eluting with ethyl acetate and hexane (1:49) to give the title compound as a pale yellow oil. Yield: 8.4 g.;

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