ChemicalBook CAS DataBase List 31712-49-9

31712-49-9

Name	ERIODICTIOL-7-GLUCOSIDE
CAS	31712-49-9
Molecular Formula	C22H24O11
MDL Number	MFCD20275042
Molecular Weight	464.42
MOL File	31712-49-9.mol

Chemical Properties

Melting point	206-207 °C
Boiling point	807.1±65.0 °C(Predicted)
density	1.569±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	7.16±0.40(Predicted)
color	White to off-white
InChIKey	ADSYMQORONDIDD-QENDSQSDNA-N
SMILES	O=C1C[C@@H](C2C=CC(OC)=C(O)C=2)OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC(O)=C12 \|&1:3,18,19,20,22,24,r\|

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

Hazard Information

Uses

Hesperetin 7-O-glucoside can be used to treat osteoporosis, scavenging free radicals, varicose veins, reducing blood lipid and decreasing blood pressure. It can also be used to promote plant growth and treat plant anti-bacterial infections.

Definition

ChEBI: A flavanone 7-O-beta-D-glucoside having hesperetin as the flavanone component.

in vivo

Hesperetin 7-O-glucoside (1 mg/kg; Oral administration; 7 days) had anti-inflammatory and protective effects in a mouse model of dextran sodium sulfate(HY-116282C) induced colitis^[2].
Hesperetin 7-O-glucoside (1-10 mg/kg; Oral gavage; 7 days) regulates intestinal flora and metabolic homeostasis in mice^[3].

Animal Model:	Dextran sodium sulfate (DSS) (HY-116282C) treated female C57BL/6N mice aged six weeks old (16-18 g)^[2]
Dosage:	1 mg/kg
Administration:	Oral administration (p.o.); 7 days
Result:	Markedly alleviated the inflammatory status in DSS-induced colitis mice, manifested by the recovered colon length from 5.91± 0.66 to 6.45 ± 0.17 cm, histopathological changes, and mRNA levels of colonic inflammatory factors including TNF-α and IL-22. Regulated the gut microbiota composition in the cecal contents and co-metabolites.

Animal Model:	Female C57BL/6N mice aged six weeks old (16-18 g)^[3]
Dosage:	1, 5 and 10 mg/kg
Administration:	Oral gavage (i.g.); 7 days
Result:	Regulated fecal microbiota and its derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan metabolites (indole and its derivatives), in feces of mice. Significantly changed urinary hippurate and trimethylamine Noxide (TMAO), co-metabolites of the microbe and host. Modulated the host tricarboxylic acid cycle (TCA) involved in energy metabolism.

target

HMG-CoA Reductase | Antifection

IC 50

IL-1β; IL-22

Spectrum Detail

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