ChemicalBook CAS DataBase List 30827-99-7

30827-99-7

Name	4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
CAS	30827-99-7
EINECS(EC#)	608-547-2
Molecular Formula	C8H11ClFNO2S
MDL Number	MFCD00132962
Molecular Weight	239.69
MOL File	30827-99-7.mol

Synonyms

4-(2-AMINOETHYL)-BENZENESULFONYL FLUORIDE 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HCL 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE 4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HYDROCHLORIDE 4-(2-AMINOETYL)-BENZENESULFONYL FLUORIDE HYDROCHLORIDE AEBSF AEBSF HCL AEBSF HYDROCHLORIDE PEFABLOC(R) SC PEFABLOC SC PEFABLOC SC PLUS TIMTEC-BB SBB003219 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HYDROCHLOR Aebsf(4-(2-Aminoethyl)BenzenesulfonylFluoride)Hydrochloride 4-(2-Aminoethyl)Benzenesulphonylfluoridehydrochloride98+% AEBSF-HCl research grade Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride AEBSF HYDROCHLORIDE (4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE) 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 98+% 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF

Chemical Properties

Appearance	white powder
Melting point	175-177 °C
bulk density	200kg/m3
storage temp.	0-6°C
solubility	H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
form	Powder
color	White
PH	pH3.0～5.0 (10g/L, 25℃)
biological source	synthetic (organic)
Water Solubility	10 g/L (20 ºC)
Sensitive	Moisture Sensitive
BRN	7604627
Stability:	Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChIKey	WRDABNWSWOHGMS-UHFFFAOYSA-N
SMILES	S(C1C=CC(CCN)=CC=1)(=O)(=O)F.Cl
CAS DataBase Reference	30827-99-7(CAS DataBase Reference)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes	C,Xi
Risk Statements	R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
RIDADR	UN 3261
WGK Germany	3
Hazard Note	Corrosive
HazardClass	8
PackingGroup	II
HS Code	29214990

Hazard Information

Description

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.

Chemical Properties

white powder

Uses

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

General Description

Pefabloc^? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.

storage

Desiccate at -20°C

References

1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292

Spectrum Detail

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