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SC-75741 is an inhibitor of NF-κB (EC₅₀ = 0.1 μM in an NF-κB reporter gene assay). It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner. It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.

SC75741 is a potent NF-κB inhibitor with EC50.

NF-κB

p65: 200 nM (IC₅₀)

[1] JOHANN LEBAN. A novel class of potent NF-κB signaling inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17 21: Pages 5858-5862. DOI: 10.1016/j.bmcl.2007.08.022
[2] CHRISTINA EHRHARDT. The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance[J]. Cellular Microbiology, 2013, 15 7: 1198-1211. DOI: 10.1111/cmi.12108
[3] EMANUEL HAASBACH . The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus[J]. Antiviral research, 2013, 99 3: Pages 336-344. DOI: 10.1016/j.antiviral.2013.06.008