Chemical Properties
Crystalline Solid
Uses
Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive.
Progestogen; antineoplastic (hormonal)
Uses
tranquilizer, neuroleptic, alpha adrenergic blocker
Description
Chlormadinone acetate is a synthetic progestin.
1 It binds to progesterone, androgen, and glucocorticoid receptors
in vitro (K
is = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.
Originator
Chlormadinone,Teikoku Hormone Mfg
Definition
ChEBI: Chlormadinone acetate is a corticosteroid hormone.
Manufacturing Process
10 g 6-dehydro-17α-acetoxy-progesterone was dissolved in 400 ml dioxane
and 40 ml water. The solution was added to 4 g N-chlorosuccinimide and 2.4
ml 70% perchloric acid. The mixture was left at ambient temperature for 24
hours, whereupon it was poured in water, a dropping precipitate was filtered
off, washed with water and dried. It was filtered through aluminum oxide and
recrystallized from ether to give 6-chloro-6-dehydro-17α-acetoxyprogesterone (chlormadinone acetate). MP: 204°-206°C. [α]D= +54.6°
(chloroform).
Brand name
Gestafortin;Luteran;Ovosiston.
Therapeutic Function
Progestin
World Health Organization (WHO)
Chlormadinone acetate, a synthetic progestogen, was introduced
in 1965 as a component in oral contraceptive preparations. In 1967, as a result of
new regulations required by the United States Food and Drug Administration,
chlormadinone acetate was submitted to long-term toxicity studies and by the early
1970s it was shown to be associated with an increased incidence of mammary
tumours in beagle bitches which led to its withdrawal by several regulatory
authorities. Subsequently the validity of the beagle bitch model as a predictor of
carcinogenicity of steroid contraceptives has been contested by many national
regulatory authorities and chlormadinone remains available in some countries for
contraceptive purposes. In some instances it is indicated for treatment of
progesterone deficiency and endometriosis, and of irregular uterine bleeding due
to fibroids.
(Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
in vitro
when compared with other progesterone derivatives, chlormadinone showed a relatively strong positional effect. chlormadinone was found to have high binding affinity to the progesterone receptor, resulting in strong progestogenic activity at the endometrium level. chlormadinone could also prevent the lh surge in the same way as progesterone. in addition, chlormadinone could weakly bind to the glucocorticoid receptor, but not to either mineralocorticoid nor estrogen receptors. chlormadinone at high doses competed effectively with androgens to block their effects and also downregulated the number of androgen receptors [1].
in vivo
results from previous rat study showed that chlormadinone at low doses, similar to cyproterone acetate, was able to selectively impaire the epididymal function and maturation of spermatozoa without appreciably changing either testicular function or pituitary gonadotrophin secretion [2].
References
[1] bouchard p. chlormadinone acetate (cma) in oral contraception--a new opportunity. eur j contracept reprod health care. 2005;10 suppl 1:7-11.
[2] sharma mm,lal g,jacob d. effects of low doses of chlormadinone acetate in the rat. j reprod fertil.1976 sep;48(1):177-9.
