SDH-IN-5 (compound 7d) is a potent succinate dehydrogenase (SDH) inhibitor, with an IC50 of 3.293 μM. SDH-IN-5 is also exhibits antifungal activity, with an EC50 of 0.046 μg/mL against R. solani. SDH-IN-5 could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies[1].
References
[1] Luo B, et, al. Design, Synthesis, and Antifungal Activities of Novel Pyrazole-4-carboxamide Derivatives Containing an Ether Group as Potential Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2023 Jun 21;71(24):9255-9265. DOI:10.1021/acs.jafc.3c00116
