ChemicalBook CAS DataBase List 2864-50-8

2864-50-8

Name	Cholesteryl sodium sulfate
CAS	2864-50-8
Molecular Formula	C27H45NaO4S
MDL Number	MFCD00079091
Molecular Weight	488.7
MOL File	2864-50-8.mol

Synonyms

3BETA-HYDROXY-5-CHOLESTENE 3-SULFATE SODIUM SALT 3-BETA-HYDROXY-5-CHOLESTENE 3-SULPHATE 5-CHOLESTEN-3BETA-OL 3-SULFATE SODIUM 5-CHOLESTEN-3BETA-OL SULFATE SODIUM SALT 5-CHOLESTEN-3-BETA-OL SULPHATE 5-CHOLESTEN-3-BETA-OL SULPHATE, SODIUM SALT CHOLESTEROL 3-SULFATE SODIUM SALT CHOLESTEROL, HYDROGEN SULFATE CHOLESTERYL SODIUM SULFATE CHOLESTERYL SODIUM SULFATE SODIUM SALT CHOLESTERYL SODIUM SULPHATE CHOLESTERYL SULFATE SODIUM CHOLESTERYL SULFATE SODIUM SALT SCS SODIUM CHOLESTERYL SULFATE CHOLESTEROL 3 SULFATE SODIUM 5-cholesten-3β-ol sulfate sodium salt CHOLESTEROL SULFATE SODIUM (SCS) SODIUM CHOLESTEROL SULFATE (3)-Cholest-5-en-3-ol 3-(Hydrogen Sulfate) Sodium Salt

Chemical Properties

Appearance	White to Off-White Solid
Melting point	178-180°C
storage temp.	2-8°C
solubility	Methanol (Slightly, Heated)
form	White to off-white powder.
color	White to Off-White
biological source	synthetic
Usage	Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones.
BRN	3899884
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChIKey	ZKMOLHRAYRDKHW-SMRZMENRNA-N
SMILES	C[C@]12CC[C@H](OS(O)(=O)=O)CC1=CC[C@@]1([H])[C@]3([H])CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]3(C)CC[C@]21[H].[NaH] \|&1:1,4,14,16,20,22,30,34,r\|
CAS DataBase Reference	2864-50-8(CAS DataBase Reference)

Safety Data

WGK Germany	3
F	3-10
Storage Class	11 - Combustible Solids

Hazard Information

Description

Cholesterol sulfate is an endogenous component of cell membranes where it serves as a substrate for steroid synthesis, influences lipid metabolism, stabilizes cell membranes, regulates the activity of functional proteins, and plays a role in keratinocyte differentiation and development of the epidermal barrier. This synthetic formulation can be used to form nonconventional liposomes in order to study cellular membrane properties.

Chemical Properties

White to Off-White Solid

Uses

Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones.

in vivo

Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 6 days) antagonizes acute ulcerative colitis induced by DSS (HY-116282C) in male C57BL/6J mice, prevents weight loss, colon shortening and tissue damage, and reverses the exacerbated symptoms in Sult2b1^△IEC mice^[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 33 days) improves survival and reduces inflammation in male C57BL/6J mice with chronic colitis induced by DSS^[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 42 days) alleviates spontaneous colitis caused by IL-10 deficiency in female IL-10^-/- mice and reduces body weight loss and tissue damage^[2].
Cholesteryl sulfate sodium (SCS) can synergize with Mitoxantrone hydrochloride (HY-13502A) to exert antitumor activity through a nano-delivery system^[3].

References

[1] CHARLES A STROTT Yuko H. Cholesterol sulfate in human physiology: what’s it all about?[J]. Journal of Lipid Research, 2003, 44 7: 1268-1278. DOI: 10.1194/jlr.r300005-jlr200

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