ChemicalBook CAS DataBase List 2835-99-6

2835-99-6

Name	4-Amino-m-cresol
CAS	2835-99-6
EINECS(EC#)	220-621-2
Molecular Formula	C7H9NO
MDL Number	MFCD00007871
Molecular Weight	123.15
MOL File	2835-99-6.mol

Synonyms

2-AMINO-5-HYDROXYTOLUENE 4-AMINO-3-CRESOL 4-AMINO-3-METHYLPHENOL 4-AMINO-M-CRESOL 4-HYDROXY-2-METHYLANILINE 4-HYDROXY-O-TOLUIDINE JAROCOL 4A3MP P-AMINO-M-CRESOL 2-Methyl-4-hydroxyaniline 3-Methyl-4-aminophenol 4-amino-3-methyl-pheno 4-amino-cresol 4-amino-m-creso 4-amino-m-cresol,4-hydroxy-o-toluidine,4-amino-3-methylphenol m-Cresol, 4-amino- Phenol, 4-amino-3-methyl- p-Hydroxy-o-toluidine 4-Amino-3-methylphenol,98% 4-amino-meta-cresol 4-Amino-m-cresol 4-Amino-3-methylphenol

Chemical Properties

Appearance	Light gray powder
Melting point	176-179 °C (lit.)
Boiling point	229.26°C (rough estimate)
density	1.0877 (rough estimate)
refractive index	1.5380 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
form	Powder
pka	10.34±0.18(Predicted)
color	Brown
Water Solubility	insoluble
BRN	2078803
Cosmetics Ingredients Functions	HAIR DYEING
InChIKey	QGNGOGOOPUYKMC-UHFFFAOYSA-N
LogP	0.51 at 22℃
CAS DataBase Reference	2835-99-6(CAS DataBase Reference)
NIST Chemistry Reference	4-Amino-3-methyl phenol(2835-99-6)
EPA Substance Registry System	2835-99-6(EPA Substance)

Safety Data

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H315-H319-H400
Precautionary statements	P273-P301+P312+P330-P302+P352-P305+P351+P338
Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S37/39:Wear suitable gloves and eye/face protection . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S36:Wear suitable protective clothing . less more
RIDADR	UN3077
WGK Germany	3
RTECS	GO6826000
F	8-10-23
TSCA	Yes
HazardClass	9
PackingGroup	III
HS Code	29222900

Hazard Information

Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Chemical Properties

Light gray powder

Uses

4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.

Application

4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.?

Definition

ChEBI: A substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.

General Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Flammability and Explosibility

Notclassified

Synthesis

The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl₂ (0.72 g, 3.80 mmol), 20 mL of CH₂Cl₂, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH₂Cl₂ was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO₃. The organic layer was dried over anhydrous Na₂SO₄ and the filtrate was concentrated under reduced pressure to afford the solid product.

Purification Methods

Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

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