2713-34-0

461-96-1

2713-34-0

The general procedure for the synthesis of 3,5-difluorophenol from 3,5-difluorobromobenzene was as follows: referring to the method described in Example 1, the feedstock was replaced with 96.5 g (0.5 mol) of 3,5-difluoro-1-bromobenzene, and Raney Ni was used as a catalyst. The reaction temperature was raised to 130 °C and pressurized to 0.8 MPa under nitrogen atmosphere. keeping the rest of the reaction conditions unchanged, 52.6 g of 3,5-difluorophenol was finally obtained, with a melting point of 39-41 °C, a yield of 80.8%, and a product purity of 99.65%.