223580-51-6

The pure product is a beige solid with mp 112.2℃, relative density 1.47 (20℃), vapor pressure 1.03×10^-6Pa, distribution coefficient 3.68 (25℃), and solubility in water at 20℃ is 13.2 mg/L.

Tiadinil is a fungicide used in pesticides on crops and vegetation to combat plant disease an death.

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid with the amino group of 3-chloro-4-methylaniline. It is a fungicide used particularly for the control of fungal diseases in rice.

Tiadinil is produced through a multistep process centred on constructing its key heterocyclic core, 4 methyl 1,2,3 thiadiazole 5 carboxylic acid, followed by amide coupling with 3 chloro 4 methyl¬aniline. Recent process development work shows that the thiadiazole intermediate can be prepared in roughly 70% yield using a hybrid continuous flow system equipped with reaction chips, which enables controlled oxidation, cyclization, and sulphur–nitrogen bond formation. Once this carboxylic acid intermediate is obtained, tiadinil is formed via a rapid condensation (amide forming) reaction. After coupling, the crude product is purified, typically by solvent extraction and crystallisation, to obtain technical grade tiadinil

Host plant defence induction

Fungicide