ChemicalBook CAS DataBase List 99-97-8

99-97-8

Name	N,N-DIMETHYL-P-TOLUIDINE
CAS	99-97-8
EINECS(EC#)	202-805-4
Molecular Formula	C9H13N
MDL Number	MFCD00008316
Molecular Weight	135.21
MOL File	99-97-8.mol

Synonyms

4-DIMETHYLAMINOTOLUENE 4,N,N-TRIMETHYLANILINE N,N,4-TRIMETHYLBENZENAMINE N,N-DIMETHYL-4-METHYLANILINE N,N-DIMETHYL-4-TOLUIDINE N,N-DIMETHYL-PARA-TOLUIDINE N,N-DIMETHYL-P-TOLUIDINE Benzeneamine,N,N,4-trimethyl- dimethyl-4-toluidine Dimethyl-p-toluidine Dimethyl-p-tolyl-amine dimethyltoluidine Dimetil-p-toluidina N,N,4-Trimethylaniline n,n,4-trimethyl-benzenamin n,n-dimethyl-p-toluidin N,N-Dimethyl-p-tolylamine p-(dimethylamino)toluene p,N,N-trimethylaniline p-Methyl-N,N-dimethylaniline

Chemical Properties

Appearance	light yellow liquid
Melting point	-25°C
Boiling point	211 °C(lit.)
density	0.937 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
vapor pressure	0.1 hPa (20 °C)
refractive index	n20/D 1.546(lit.)
Fp	182 °F
storage temp.	Store below +30°C.
solubility	0.65g/l
form	Liquid
pka	pK1:7.24(+1) (25°C)
color	Clear yellow
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
explosive limit	7%
Water Solubility	Miscible with alcohol, ether and chloroform. Immiscible with water.
BRN	774409
Henry's Law Constant	2.0×10^-1 mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Dielectric constant	3.3（20℃）
Cosmetics Ingredients Functions	NAIL SCULPTING
InChI	1S/C9H13N/c1-8-4-6-9(7-5-8)10(2)3/h4-7H,1-3H3
InChIKey	GYVGXEWAOAAJEU-UHFFFAOYSA-N
SMILES	CN(C)c1ccc(C)cc1
LogP	1.729-2.81 at 35℃
CAS DataBase Reference	99-97-8(CAS DataBase Reference)
IARC	2B (Vol. 115) 2018
EPA Substance Registry System	N,N,4-Trimethylaniline (99-97-8)

Safety Data

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301+H311-H330-H373-H412
Precautionary statements	P260-P273-P280-P302+P352+P312-P304+P340+P310-P314
Hazard Codes	T
Risk Statements	R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R33:Danger of cumulative effects. R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . less more
Safety Statements	S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) . S36/37:Wear suitable protective clothing and gloves . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S61:Avoid release to the environment. Refer to special instructions safety data sheet . less more
RIDADR	1708
WGK Germany	3
RTECS	XU5803000
F	8-10-23
Autoignition Temperature	425 °C
TSCA	Yes
REACH Registrations	Active
HazardClass	6.1
PackingGroup	II
HS Code	29214300
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Chronic 3 Carc. 1B Repr. 2 Skin Sens. 1 STOT RE 2 Oral
Hazardous Substances Data	99-97-8(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 1650 mg/kg less more

Raw materials And Preparation Products

Hazard Information

General Description

A clear colorless liquid with an aromatic odor. Density 0.937 g/cm3 (Lancaster) and insoluble in water. Hence floats on water. Toxic by skin absorption and inhalation. Flash point 181°F. May release toxic vapors when burned.

Reactivity Profile

N,N-DIMETHYL-P-TOLUIDINE(99-97-8) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Air & Water Reactions

Tends to darken upon exposure to air. Insoluble in water.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Chemical Properties

light yellow liquid

Uses

N,N-Dimethyl-4-toluidine is an amine accelerator for the polymerization of e.g. dental methacrylic restorative materials

Synthesis Reference(s)

Synthetic Communications, 19, p. 3051, 1989 DOI: 10.1080/00397918908052700
Tetrahedron Letters, 8, p. 1849, 1967

Synthesis

N,N-Dimethyl-p-toluidine was prepared by reacting p-toluidine with methanol and POCl3 in autoclave heated up to 280° C for 3h.

Purification Methods

Reflux for 3hours with 2 molar equivalents of Ac2O, then fractionally distil it under reduced pressure. Alternatively, dry it over BaO, distil and store it over KOH. The picrate has m 128o (from EtOH). Methods described for N,N-dimethylaniline are applicable here. [Beilstein 12 H 902, 12 III 2026, 12 IV 1874.]

Toxics Screening Level

The initial threshold screening level (ITSL) for n,n-dimethyl-p-toluidine (DMPT), is 28 μg/m3 based on an annual averaging time.

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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