Chemical Properties
White Solid
Description
Tulathromycin A is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers. Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.
Uses
Triamilide antibiotic for treatment of bovine and porcine respiratory disease. Exists as an equilibrium mixture of two isomeric forms, Tulathromycin A (90%) and B (10%). Antibacterial.
Uses
Tulathromycin is a semi-synthetic erythromycin belonging to the ring expanded aza–erythromycins. Ring expansion improvedsthe acid lability of the parent erythromycins. Tulathromycin is regarded as the first of the triamilides, having a third amino (propylaminomethylene) group on a sugar to improve absorption. This modification provides a mixture of the two tulathromycin isomers (90:10) present in the commercial animal health product.
Uses
Tulathromycin is a semi-synthetic erythromycin belonging to the ring expanded aza–erythromycins. Ring expansion improves the acid lability compared with the parent erythromycins. Tulathromycin is regarded as the first of the triamilides, having a third amino (propylaminomethylene) group on a sugar to improve absorption. This modification provides a mixture of the two tulathromycin isomers (90:10) present in the commercial animal health product.
Definition
ChEBI:Tulathromycin A is an aminoglycoside.
Biological Activity
Tulathromycin, like other macrolides, exerts therapeutic benefits not solely explainable by antibacterial activity. Like azithromycin, tulathromycin A may have multiple immunomodulatory effects that likely contribute to the therapeutic response in respiratory infections and perhaps other diseases[1]. Other beneficial effects may be caused by enhanced degranulation and apoptosis of neutrophils and inhibition of inflammatory cytokine production. It also may help clear infections by enhancing macrophage functions.
Pharmacokinetics
The half-life is long, with 80- to 90-hour plasma half-life in pigs and cattle, and 8- and 6-day tissue half-life in cattle and pigs, respectively, which prolongs the drug concentration at the site of infection. The volume of distribution is greater than 10 L/kg. Absorption from injection is greater than 80% in cattle and pigs. Tulathromycin A concentrates in bronchoalveolar cells, and concentrations are detectable for at least 8 days after a single administration, although they are still lower than the MIC for R. equi (greater than 64 μg/mL)[1-2].
Mode of action
Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.
References
[1] Mark G, et al. Tulathromycin. Papich Handbook of Veterinary Drugs (Fifth Edition), 2021; 949-951.
[2] Jennifer L, et al. Pharmacologic Principles. Equine Internal Medicine (Fourth Edition), 2018; 79-137.
