21746-40-7

This thiol-reactive reagent (FW = 139.15 g/mol; CAS 21746-40-7), also known as NPM and 1-propyl-1H-pyrrole-2,5-dione, readily alkylates protein sulfhydryl groups. Under alkaline conditions it can also react with amino groups. Some enzymes are inactivated at faster rates with analogues having longer alkyl chains (e.g., the inactivation rate of yeast alcohol dehydrogenase with N-octylmaleimide is significantly faster than with N- ethylmaleimide1). See also N-Ethylmaleimide Target (s) : acylglycerol lipase, or monoacylglycerol lipase.