215307-86-1

BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery.

BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα.

RARα

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