2052-07-5

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• Description

  2-Bromobiphenyl is an important intermediate, which can be used to synthesize 2,2'-dibromo-9,9'-spirobifluorene, 3-bromo-9-(9-phenylfluoren-9-yl)carbazole and phenanthrene compounds.;

• Uses

  2-Bromobiphenyl can be used as reference compound to investigate extraction efficiency of solid-phase microextraction fibers, based on methacrylic acid-trimethylolpropanetrimethacrylate copolymers.

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• synthesis

  Carry out all catalytic reactions in reaction vessels open to the air. Charge a round-bottom flask with the newly purchased or freshly recrystallized aryl boronic acid (2.0 mmol), 1,2-dibromobenzene, powdered K3PO4 (2.2 mmol) and toluene (2.5 mL) of technical quality. Stir the mixture vigorously. Heat the mixture to 80 °C for 10 minutes. Add (0.2 mol%) of catalyst by syringe as a 2.5 ml of toluene solution to the mixture. Take the samples periodically from the reaction mixture. Quench the reaction with water. Extract the mixture with ethyl acetate. Analyze the reaction by GC-MS. At the end of catalytic reaction, cool the reaction mixture to room temperature. Quench the mixture with water (adjusted to an appropriate pH when biaryls with acidic or basic groups has to be extracted). Extract the mixture with ethyl acetate (3×40 mL). Dry the combined extracts (MgSO4). Evaporate the combined extracts to dryness. Purify the crude material by flash chromatography on silica gel.;

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