ChemicalBook CAS DataBase List 20325-40-0

20325-40-0

Name	3,3'-Dimethoxybenzidine dihydrochloride
CAS	20325-40-0
EINECS(EC#)	243-737-5
Molecular Formula	C14H18Cl2N2O2
MDL Number	MFCD00012488
Molecular Weight	317.21
MOL File	20325-40-0.mol

Synonyms

3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine dihydrochloride 3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE 4,4'-DIAMINO-3,3'-DIMETHOXYBIPHENYL DIHYDROCHLORIDE BLUE BN BASE DIHYDROCHLORIDE DIMETHOXYBENZIDINE DIHYDROCHLORIDE DMB DIHYDROCHLORIDE FAST BLUE B FAST BLUE B BASE DIHYDROCHLORIDE O-DIANISIDINE DIHYDROCHLORIC ACID O-DIANISIDINE DIHYDROCHLORIDE O-DIANISIDINE REAGENT (1,1’-Biphenyl)-4,4’-diamine,3,3’-dimethoxy-,dihydrochloride 1’-biphenyl)-4,4’-diamine,3,3-dimethoxy-(dihydrochloride 1’-biphenyl]-4,4’-diamine,3,3’-dimethoxy-[dihydrochloride 3,3’-dimethoxy-4,4’-diaminobiphenyldihydrochloride 3,3’-dimethoxy-benzidindihydrochloride c.i.disperseblack6dihydrochloride o-Dianisidinehydrochloride 3,3-dimethoxybiphenyl-4,4-ylenediammonium dichloride ortho-dianisidine dihydrochloride

Chemical Properties

Appearance	Off-white or grey tablets
Melting point	268 °C
Fp	206℃
storage temp.	2-8°C
solubility	H2O: soluble25mg/mL
form	tablet
color	Light beige to purple-gray
PH	1.7 at 20℃ and 100g/L
Water Solubility	1-5 g/100 mL at 20 ºC
BRN	3917996
Major Application	diagnostic assay manufacturing hematology histology
InChI	InChI=1S/C14H16N2O2.ClH/c1-17-13-7-9(3-5-11(13)15)10-4-6-12(16)14(8-10)18-2;/h3-8H,15-16H2,1-2H3;1H
InChIKey	UXTIAFYTYOEQHV-UHFFFAOYSA-N
SMILES	O(C1=C(C=CC(C2C=CC(N)=C(OC)C=2)=C1)N)C.Cl
CAS DataBase Reference	20325-40-0(CAS DataBase Reference)
EPA Substance Registry System	20325-40-0(EPA Substance)

Safety Data

Hazard Codes	T
Risk Statements	R45:May cause cancer. R22:Harmful if swallowed. less more
Safety Statements	S53:Avoid exposure-obtain special instruction before use . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	2811
WGK Germany	3
RTECS	DD1050000
TSCA	Yes
REACH Registrations	Active
HazardClass	6.1(a)
PackingGroup	II
HS Code	29222990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Carc. 1B Eye Dam. 1 Skin Corr. 1
Safety Profile	Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental reproductive data. Mutation data reported.When heated to decomposition it emits very toxic fumes of NO, and HCl. less more

Raw materials And Preparation Products

Hazard Information

General Description

Off-white powder.

Reactivity Profile

3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE(20325-40-0) is an ether substituted acidic organic salt. Reacts weakly as a acid to neutralize bases. May react with strong oxidizing agents or strong reducing agents.

Air & Water Reactions

Water soluble.

Fire Hazard

Flash point data are not available for this chemical, but 3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE is probably combustible.

Description

o-Dianisidine (dihydrochloride) is a colorimetric peroxidase substrate that has been used as a substrate to semi-quantitatively measure lactate, uric acid (Item No. 16219), and glucose. It has also been used as a reagent for the detection of various metals, thiocyanates, and nitrites. This aromatic amine is initially colorless but turns to violet upon oxidization and is spectrophotometrically measured at a wavelength of 405 nm.

Chemical Properties

Off-white or grey tablets

Uses

o-Dianisidine (3,3′-dimethoxybenzidine) has been used as a component of GO (glucose oxidase) reagent, which is used for measuring the glucose content. It has also been used as a substrate to measure myeloperoxidase activity.

Uses

It is suitable for use in ELISA procedures. In neurohistochemistry o-Dianisidine dihydrochloride has demonstrated perikaryal labeling as well as retrograde and anterograde transport to the primary olfactory cortex. It has also been used for a paper based-micro fluidic device to semi-quantitatively measure lactate, uric acid, and glucose. 3,3'-Dimethoxybenzidine is used principally as an intermediate in the production of commercial bisazobiphenyl dyes for coloring textiles, paper, plastic, rubber, and leather.

References

[1] MAMORU SUGIURA Kazuyuki H. A new colorimetric method for determination of serum glucose[J]. Clinica Chimica Acta, 1977, 75 3: Pages 387-391. DOI: 10.1016/0009-8981(77)90357-6
[2] M M MESULAM D L R. Sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods.[J]. Journal of Histochemistry & Cytochemistry, 1979, 27 3: 763-773. DOI: 10.1177/27.3.113450
[3] 3,3’-Dimethoxybenzidine and dyes metabolized to 3,3’-dimethoxybenzidine: 3,3’-dimethoxybenzidine.[J]. Report on carcinogens?: carcinogen profiles, 2011, 12: 164-165.

Material Safety Data Sheet(MSDS)

Spectrum Detail

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