ChemicalBook CAS DataBase List 1965291-08-0

1965291-08-0

Name	Ibrexafungerp citrate
CAS	1965291-08-0
Molecular Formula	C50H75N5O11
Molecular Weight	922.17
MOL File	1965291-08-0.mol

Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Uses

Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections[1].

in vivo

Pharmacokinetic Analysis
Ibrexafungerp citrate (MK 3118 citrate) exhibits oral bioavailability (mouse 51%, rat 45%, dog 35%) following oral administration (mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg)^[3].
Ibrexafungerp citrate (MK 3118 citrate) exhibits moderate half-lives (mouse 5.5, rat 8.7 and, dog 9.3 h) due to high plasma clearance (0.68, 0.44, and 0.45 L/h/kg respectively) combined with large volumes of distribution (5.3, 4.7, and 4.1 L/kg respectively) following intravenous administration (mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg)^[3].

Animal Model:	Female CD1 mice, Male and female Han Wister rats, Male and female beagle dogs^[3]
Dosage:	Mice (1 mg/kg), rats (5 mg/kg) and dogs (5 mg/kg)
Administration:	Intravenous (i.v.) or oral gavage
Result:	T_1/2s of 5.5, 8.7, and 9.3 h for mice, rats, and dogs, respectively.

References

[1] James M Apgar, et al. Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. Bioorg Med Chem Lett. 2021 Jan 15;32:127661. DOI:10.1016/j.bmcl.2020.127661
[2] Mahmoud Ghannoum, et al. Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections. Antibiotics (Basel). 2020 Aug 25;9(9):539. DOI:10.3390/antibiotics9090539
[3] Stephen A Wring, et al. Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02068-16. DOI:10.1128/AAC.02068-16

Supplier

mahaloong

Telephone028-81192082 18180560816

Websitehttps://www.mahaloong.com

Chongqing Qiantai Pharma Co., Ltd.

Telephone 15862471140

Websitehttps://www.qiantai-pharma.com

Shanghai Zhibang Biological Medicine Co., LTD

Telephone021-54285032 18116461626

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30507/0_EN.htm

Dideu Industries Group Limited

Telephone+86-29-89586680 +86-15129568250

Websitehttps://www.dideu.com

Wuhan Ruilida Biomedical Technology Co., Ltd.

Telephone 18201884268

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31333/0_EN.htm

Guangzhou Younan Technology Co., Ltd

Telephone020-82000279 18988941452

Websitehttp://www.ubiochem.cn/

Taizhou Nanfeng Pharmaceutical Research Institute

Telephonenanfengpharma@126.co 18616377689

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1580880/0.htm

Chengdu ruihede Medical Technology Co., Ltd

Telephone 17381862311

Websitehttps://www.ruihede.cn

Suzhou Biosyntech Co., Ltd.

Telephone+86-0512-63001269 15720870325

Websitehttp://www.biosyntech-suzhou.com/default.aspx

Nantong Hi-Future Biotechnology Co., Ltd

Telephone+86-0513; 18051384581

Websitehttps://www.chemhifuture.com/

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Telephone 18171815831

Websitehttp://www.shenlansw.com/

Shanghai Tachizaki Biomedical Research Center

Telephone 18014399201

Websitehttp://www.chemlab-tachizaki.com/

Suzhou Haiben Pharmaceutical Co., Ltd

Telephone19353112242

Website

CDYXYL

Telephone 13688280140

Website

Zhejiang Huida Biotech Co., Ltd.

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

Chongqing Qiantai Pharma Co., Ltd.

Telephone 17864179792

Websitehttps://www.qiantai-pharma.com

Chongqing jooe co., ltd

Telephone +86-15223382610

Websitehttps://www.jooe.com/

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Telephone+86-18600796368

Websitehttp://www.sjar-tech.com/

1of4

Related Products

Send Inquriy