1-Bromo-2-nitrobenzene (10.0 g, 49.5 mmol, 1.0 eq.) and pinacol ester of bis(diphenylphosphine) (15.08 g, 59.4 mmol, 1.2 eq.) were added with potassium acetate (14.57 g, 148 mmol, 3.0 eq.) and [1,1'-bis(diphenylphosphino)palladium(II) dichloride] (1.09 g, 1.49 mmol, 0.03 equiv) in dioxane (180 mL). The reaction mixture was stirred at 80 °C for 12 hours under nitrogen protection. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 100:1 to 80:1) afforded 2-nitrophenylboronic acid pinacol ester as a yellow oil (12.0 g, 97% yield). The product was identified by 1H NMR (DMSO-d6, 400 MHz): δ 8.17 (d, J = 8.0 Hz, 1H), 7.67-7.65 (m, 1H), 7.58-7.54 (m, 2H), 1.44 (s, 12H).
