Fleephilone is a fungal metabolite that can be isolated from Trichoderma harzianum. Fleephilone is a HIV REV/RRE binding inhibitor. Fleephilone inhibits the binding of REV-protein to RRE RNA with an IC50 of 7.6 μM[1].
References
[1] Qian-Cutrone J, et al. Harziphilone and fleephilone, two new HIV REV/RRE binding inhibitors produced by Trichoderma harzianum. J Antibiot (Tokyo). 1996 Oct;49(10):990-7. DOI:10.7164/antibiotics.49.990
