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98-92-0

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Identification

Name
Nicotinamide
CAS
98-92-0
Synonyms
3-PYRIDINECARBOXAMIDE
3-PYRIDINE CARBOXYLIC ACID AMIDE
3-PYRIDINECARBOXYLIC AMIDE
NIACINAMIDE
NICETHAMIDUM
NICOTINAMIDE
NICOTINIC ACID AMIDE
PYRIDINE-3-CARBOXAMIDE
PYRIDINE-3-CARBOXYLIC ACID AMIDE
TIMTEC-BB SBB004283
VITAMIN B3
VITAMIN B3/B5
VITAMIN PP
-(Aminocarbonyl)pyridine
3-Carbamoylpyridine
3-Pyridinecarboxyamide
Acid amide
acidamide
Amid kyseliny nikotinove
Amide PP
EINECS(EC#)
202-713-4
Molecular Formula
C6H6N2O
MDL Number
MFCD00006395
Molecular Weight
122.12
MOL File
98-92-0.mol

Chemical Properties

Appearance
White crystalline powder
Melting point 
128-131 °C(lit.)

mp 
128-131 °C(lit.)

Boiling point 
150-160 °C
bp 
150-160 °C
density 
1.40
vapor density 
4.22 (vs air)

refractive index 
1.4660 (estimate)
Fp 
182 °C
storage temp. 
0-6°C
solubility 
691g/l
pka
3.3(at 20℃)
form 
powder

color 
white

Stability:
Stable. Incompatible with strong oxidizing agents.
Odor
Odorless
PH Range
9
PH
6.0-7.5 (50g/l, H2O, 20℃)
Water Solubility 
1000 g/L (20 ºC)
Decomposition 
>=200 °C
Usage
Niacinamide USP DC is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals WWW Link
Usage
Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics. WWW Link
Detection Methods
HPLC,NMR
Merck 
14,6523
BRN 
383619
InChIKey
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Uses
Niacinamide is a nutrient and dietary supplement that is an available form of niacin. Nicotinic acid is pyridine beta-carboxylic acid and nicotinamide, which is another term for niacinamide, is the corresponding amide. It is a powder of good water solubility, having a solubility of 1 g in 1 ml of water. Unlike niacin, it has a bitter taste; the taste is masked in the encapsulated form. Used in fortification of cereals, snack foods, and powdered beverages.
Uses
niacinamide is used as a skin stimulant and skin smoother. It is a derivative of niacin, and part of the vitamin B family.
CAS DataBase Reference
98-92-0(CAS DataBase Reference)
NIST Chemistry Reference
Niacinamide(98-92-0)
EPA Substance Registry System
98-92-0(EPA Substance)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1

RTECS 
QS3675000


8
Autoignition Temperature
480 °C
TSCA 
Yes
HS Code 
29362990
Safety Profile
Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data
98-92-0(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
White powder.
Reactivity Profile
An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Air & Water Reactions
Water soluble.
Potential Exposure
Used as a dietary supplement and food additive.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Incompatibilities
Combustible solid; dust may form explosive mixture with air. Amides are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Originator
Niacinamide,Twinlab
Definition
ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Manufacturing Process
Gaseous ammonia was passed into nicotinic acid at a temperature between 200-235°C until the conversion to nicotinamide was 85%. The reaction mixture was colored light brown. The reaction mass was cooled and grounds to a fine powder. Fifty grams of this crude nicotinamide were boiled with 500 ml of anhydrous ethyl acetate until a dark solution was. obtained. A little solid remained in suspension. Gaseous ammonia was passed in below the surface of the ethyl acetate at a temperature between 60-70°C. After a short time ammonium nicotinate started to precipitate out of solution as a brown solid. Sufficient gaseous ammonia, was passed into the ethyl acetate solution to insure complete precipitation of the nicotinic acids as ammonium nicotinate. The solution was filtered at about 60-70°C. The filter cake consisted of ammonium nicotinate, which, upon drying, weighed 12.4 grams. The filtrate was stirred arid boiled for 20 minutes with one-half gram of activated carbon and two grams of activated adsorbent clay. The mixture was filtered hot. The filtrate was boiled twenty minutes with one-half gram of activated carbon and two grams of activated adsorbent clay and then filtered hot. The carbon and clay treatment was repeated once more. The final filtrate was cooled slowly with stirring to room temperature to precipitate white crystalline nieocinamide which, upon drying, weighed 26.7 grams and had a melting point of 129.5°C, and was over 99 percent pure. The mother liquor from the above filtration was boiled down to one-third of its volume and cooled to room temperature. A second crop of nicotinamide of three grams was obtained.
Therapeutic Function
Enzyme cofactor vitamin
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 5774, 1954 DOI: 10.1021/ja01651a043
Tetrahedron Letters, 36, p. 8657, 1995 DOI: 10.1016/0040-4039(95)01785-G
Clinical Use
Niacin is used in the treatment of niacin deficiency, which is referred to as pellagra (from the Italian, pelle for “skin” and agra for “dry”). The major systems affected are the gastrointestinal tract (diarrhea, enteritis and stomatitis), the skin (dermatitis), and the CNS (generalized neurological deficits including dementia). Pellagra has become a rare condition in the United States and other countries that require or encourage enrichment of wheat flour or fortification of cereals with niacin. Because the nucleotide form can be synthesized in vivo from tryptophan, pellagra is most often seen in areas where the diet is deficient in both niacin and tryptophan. Typically, maize (corn)-based diets meet this criteria. Niacin deficiency can also result from diarrhea, cirrhosis, alcoholism, or Hartnup disease. It is interesting that niacin deficiency can also, rarely, result from vitamin B6 deficiency (see Vitamin B6 section). Niacin, but not niacinamide, is also one of the few vitamins that are useful in the treatment of diseases unrelated to deficiencies.
Purification Methods
Crystallise niacin from *benzene. It has solubility in g/ml: H2O (1), EtOH (0.7) and glycerol (0.1). [Methods in Enzymology 66 23 1980, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 83 1971, Beilstein 22 III/IV 389, 22/2 V 80.]

Material Safety Data Sheet(MSDS)

Questions And Answer

description
Nicotinamide is also called vitamin B3 or vitamin PP, is a kind of water-soluble vitamin, belong to B vitamin, as NAD (nicotinamide adenine dinucleotide, NAD) and NADP (nicotinamide adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of nicotinamide in the body part of this two kinds of structure of coenzyme the reversible, play a role of hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation process and the new supersedes the old, having a great significance in maintaining normal tissue, especially the integrity of the skin digestive tract and the nervous system. When the lack of B vitamins, due to respiration and metabolism of cells affected by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis and so on. In addition, this product has prevention of heart block and improving the sinoatrial node and anti-fast experimental arrhythmia function, can significantly improve Vera Pammy induced bradycardia and atrioventricular block. The clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, all block can disappear, has obvious curative effect in sick sinus syndrome, right bundle branch block effect is poor. After the stomach intestinal absorption by the oral, intramuscular absorption faster, then absorption distribution to the body tissues, t1/2 is 45 min. The liver metabolism, most metabolize N-n-methylnicotinamide, only a small amount of treatment as the prototype from the urine was more than necessary. If the daily urinary excretion of N-methyl nicotinamide is lower than 4mg, suggesting that nicotinamide deficiency.
Nicotinamide and nicotinic acid are collectively referred to vitamin PP, nicotinic acid in the animal body is involved in metabolic processes in the form of nicotinamide, both have a common vitamin activity. It is white crystalline powder, odorless or almost odorless, bitter taste, easily soluble in water or ethanol, soluble in glycerol. Hygroscopic weak stable., acid, alkali and high temperature. The nature mainly exists in cereal skin, yeast, peanuts, meat, animal organs, milk and green leafy vegetables, in the body it is from tryptophan synthesis, but the efficiency is very low. Escherichia coli in the intestine (Escherichia coli) can be converted into synthesis of nicotinic acid, nicotinamide. Prevention and treatment of pellagra, exposed parts of symmetric dermatitis, stomatitis, glossitis, anorexia, dermatitis, liver disease, coronary heart disease, atrioventricular block, sick sinus syndrome, diarrhea, neuritis and dementia.
[Adverse reaction] Occasionally dizziness, nausea, abdominal discomfort, loss of appetite, disappear on their own, in early pregnancy overdose possible teratogenic intramuscular injection can cause pain, so less.
The above information is Chemicalbook Hanya edited.
Chemical Properties
It is white needle crystal or crystalline powder, no smell or odor slightly, slightly bitter taste. The relative density is 1.4, melting point is 131-132 ℃.1 g of the above the product is soluble in 1 ml of water, 1.5 ml ethanol or 10 ml glycerin, insoluble in ether. The pH of 10% aqueous solution is 6.5-7.5. in dry air to light and heat stability, in alkaline or acidic solution, heating generation to nicotinic acid. Rats by oral LD502.5-3.5g/kg ADI value does not make special provisions (ECC, 1990)
Uses
Same as nicotinic acid. Water soluble is better than niacin acid, easy to generate complex agglomerate with vitamin C. The dosage is 30-80 mg/kg.
Nicotinamide and nicotinic acid are in common use generally and nicotinic acid can transform into nicotinamide in animals. Lack of nicotinic acid and nicotinamide, results in pellagra. So they can prevent pellagra. They also play a role in the metabolism of protein and sugar, which can improve human and animal nutrition. In addition to be used as a medicine, it can also be applied in food and feed additives. The production capacity is more than 30000 tons in the world. In Japan, niacinamide used in medicine (40%), feed additives (50%) and food additives (10%). Nicotinic acid and nicotinamide are non-toxic, naturally contains in liver, kidney, yeast and honey. The niacinamide LD50 of subcutaneous injection for rat is 1.7 g/kg.
It is of Vitamin drugs, and involved in metabolic process. Can be used in skin care products, to prevent coarse skin, maintain healthy skin cells, and promote skin whitening. In addition, it can also be used in hair care products, to promote scalp blood circulation, healthy hair follicles, promotes hair growth and prevent alopecia.
Used in biochemical research. To prepare tissue culture medium. The pharmaceutical industry.
Toxicity
LD50 2.5~3.5 g/kg (rats, through the mouth).
GRAS(FDA,§182.5535,2000).
ADI is no special regulation (EEC, 1990).
Synthesis
1.β-methyl pyridine is oxidized to nicotinic acid by air, and the latter is produced by the action of ammonium hydroxide, and then heating and dehydration.
2.Nicotinic acid, boric acid and ammonia into reaction pot, stirring at the condition of ammonia gas, heating dissolution; then distilled ammonia recovery, to 120℃ after the immigration dewatering pot continues to enrich; when the temperature reached 145 ℃, start adding liquid ammonia, and in 185 to 190℃ to ammonia reaction 20~30h. And then cooled to 130℃, diluted with distilled water, activated carbon was added, and in 70~80℃through ammonia decolorization 2h; reaction after filtered, , filtrate in 24 hours after analysis of cold water, fractional crystallization and washing with ethanol, and drying to obtain the finished product. The yield was 89%.
3. From the nicotinic acid and ammonia react into salt and then dehydrated.

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