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Argyrin B, a natural product cyclic peptide, is a reversible, non-competitive immunoproteasome inhibitor. Argyrin B shows selective inhibition of the β5i and β1i sites of the immunoproteasome over the β5c and β1c sites of the constitutive proteasome with nearly 20-fold selective inhibition of β1i over the homologous β1c. Argyrin B has antibacterial effects[1].

[1] Allardyce DJ, et al. Argyrin B, a non-competitive inhibitor of the human immunoproteasome exhibiting preference for β1i. Chem Biol Drug Des. 2019 Aug;94(2):1556-1567. DOI:10.1111/cbdd.13539