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Hazard Information

Chemical Properties

clear colourless to slightly yellow liquid

Uses

5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.

Application

5-Chlorovaleryl chloride is an important medicine and pesticide intermediate. It is pharmaceutically mainly for the manufacture of the medicine Cilostazole (Cilostazol) for anti-platelet aggregation, protection of vascular endothelial cells, and atherosclerosis.5-Chlorovaleryl Chloride is also for the production of paddy rice New-type wide-spectrum weedicide pyraclonil (Pyraclonil).

General Description

5-Chlorovaleroyl chloride is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.

Flammability and Explosibility

Notclassified

Synthesis

In the existing process, producing 5-Chlorovaleryl chloride using 1,4-dichlorobutane as raw material requires a three-step reaction. First, 1,4-dichlorobutane and sodium cyanide solution are combined to form 5-chlorovaleronitrile. Then, the prepared 5-chlorovaleronitrile is hydrolyzed in concentrated hydrochloric acid to form 5-chlorovaleric acid. Finally, 5-chlorovaleronitrile reacts with thionyl chloride to generate 5-chlorovaleryl chloride.

Material Safety Data Sheet(MSDS)

Questions And Answer

• Description

  5-Chlorovaleryl chloride is an important synthetic intermediate of pyrazole herbicides. 5-Chloropentanoyl chloride is used as the raw material of 1,1,7-trichloro-1-hepten-3-one, and then the third-generation pyrazole herbicides can be synthesized. Pyrazole herbicides have the characteristics of ultra-efficient herbicidal activity, high selectivity, extremely low mammalian toxicity and good environmental characteristics, and have become a hot spot in the research and development of herbicides in the world in recent years.;

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