ChemicalBook CAS DataBase List 157-06-2

157-06-2

Name	D(-)-Arginine
CAS	157-06-2
EINECS(EC#)	205-866-5
Molecular Formula	C6H14N4O2
MDL Number	MFCD00063116
Molecular Weight	174.2
MOL File	157-06-2.mol

Chemical Properties

Appearance	white to light yellow crystal powde
Melting point	226 °C (dec.) (lit.)
alpha	-28.5 º (c=8, 6 N HCl)
Boiling point	305.18°C (rough estimate)
density	1.2297 (rough estimate)
refractive index	-23 ° (C=8, 6mol/L HCl)
storage temp.	Store at 0-5
solubility	Aqueous Acid (Slightly), Water (Slightly)
form	Solid
pka	2.49±0.24(Predicted)
color	White to Off-White
Water Solubility	SOLUBLE
Specific Heat Capacity	Cp(crystal):1.3318J/(g·K),at 25℃
Sensitive	Air Sensitive
Detection Methods	HPLC,NMR
BRN	1725412
Major Application	peptide synthesis
InChI	1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1
InChIKey	ODKSFYDXXFIFQN-SCSAIBSYSA-N
SMILES	N[C@H](CCCNC(N)=N)C(O)=O
LogP	-0.999 (est)
CAS DataBase Reference	157-06-2(CAS DataBase Reference)
EPA Substance Registry System	157-06-2(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264-P280i-P337+P313-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	R36:Irritating to the eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	CF1934220
F	9
TSCA	Yes
HazardClass	IRRITANT
HS Code	29252900
Storage Class	11 - Combustible Solids

Raw materials And Preparation Products

Hazard Information

Chemical Properties

white to light yellow crystal powde

Uses

Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.

Definition

ChEBI: A D-alpha-amino acid that is the D-isomer of arginine.

in vivo

D-arginine (1 mg/kg, i.v., caudal veins, every two days) sensitize osteosarcoma to radiotherapy in a mouse model of subcutaneous osteosarcoma^[3].
The number of D-arginine residues in cell-penetrating peptides (i.v.) significantly affects their cellular uptake behavior and systemic toxicity in mice^[4].
D-Arginine (700 mg/kg, i.p.) displays central stimulant properties and increases spontaneous motor activity in mice^[5].
D-arginine (i.p.) shows a light toxicity order (LD50: 2800 mg/kg) in mice^[5].
D-arginine (1400 mg/kg, i.p.) protects against Pentylenetetrazole-induced convulsions in mice^[5].
D-arginine (1000 mg/kg, p.o., 16 weeks) significantly alters various enzymes and metabolites in the arginine metabolic pathways in male SD rats^[6].
D-arginine (1000 mg/kg, s.c., coadministered with L-arginine) blocks antinociception elicited by L-arginine (HY-N0455) in mice with Carrageenin-induced hyperalgesia^[7].
D-arginine (20 mg/kg, s.c.) does not significantly alter the percentage of antinociception in mice^[8].

Animal Model:	Female BALB/c mice (anesthetized by intraperitoneal injection of 3% pentobarbital sodium; K7M2 cells were injected subcutaneously; X-ray irradiation)^[2]
Dosage:	1 mg/kg
Administration:	Intravenous injection (i.v.), caudal veins, every two days
Result:	Inhibited tumor volume (20 days).

IC 50

Human Endogenous Metabolite

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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