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• Indications

  Oxyfedrine is a vasodilator and has been used in angina pectoris and myocardial infarction. ;

• Mode of action

  Vasodilator, beta-sympathomimetic due to its metabolite norephedrine. ;

• Pharmacokinetics

  Oxyfedrine is almost completely (75 to 100% of a dose) metabolized to norephedrine (see there), but the organ of biotransformation is not exactly known. It has not yet been decided whether oxyfedrine is metabolized by liver enzymes, as in rats, or is spontaneously degraded eventually in the duodenal fluid before absorption when administered orally. Both organs seem to be involved because the degree of metabolism is the same after parenteral or oral administration; however, entero-hepatic circulation is known. ;

• Side effects

  Reversible loss of taste sensation. ;

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