14548-39-1

White to yellow crystalline powder or needles

6-Bromo-1-indanone is used as an organic chemical synthesis intermediate.

6-Bromoindanone (14548-39-1) is a synthetic intermediate compound used in the preparation of porous poly-schiffine materials. This material exhibits strong adsorption capacity for dyes such as Direct Blue 86, Methyl Orange, Methyl Red, Alizarin T and Rhodamine B. It is suitable for applications such as the removal of dyes from wastewater and water purification.

6-Bromoindanone synthesis: Trifluoromethanesulfonic acid (0.35 mL, 4 mmol) was added to anhydrous CHCl3 or CH2Cl2 (2 mL) solution of amide substrate 6 (1 mmol). The mixture was stirred for 4 h and then poured into ice. The product was extracted into CHCl3, and the organic solution was washed with H2O, brine and dried with anhydrous sodium sulfate. The crude product was isolated and purified by column chromatography (hexane:ethyl acetate). Recovery of nitro-substituted aniline: The aqueous extract was made basic by the addition of 10MNaOH and the solution was extracted with CHCl3. The organic solution was washed with H2O, brine (2x) and dried over anhydrous sodium sulfate to yield 6-bromoindanone in 88% yield.

[1] Erum K. Raja. (2012). Friedel–Crafts Acylation with Amides. Journal of Organic Chemistry, 77 13, 5788–5793. https://doi.org/10.1021/jo300922p