34598-49-7

5-Bromo-1-indanone(34598-49-7) is a 1-indanone derivative. Its physical properties like density, freezing point and refractive index have been determined. It participates in the synthesis of the imidazolyl and triazolyl substituted biphenyl compounds.

white to light yellow crystal powder

Starter for indanone-based pharmaceuticals1,2

5-Bromo-1-indanone(34598-49-7) is a pharmaceutical intermediate compound that is a raw material for the preparation of indanone-based pharmaceuticals. It is also used as a chemical reagent for the preparation of other indanones such as 2,3,5 tribromoindanone by bromination^[1].

GENERAL STEPS: Be safe. Tert-butyl hydroperoxide (TBHP) is highly reactive, flammable and toxic, corrosive to skin and mucous membranes, and may cause respiratory distress by inhalation. A solution of 5-bromo-2,3-dihydro-1H-inden-1-ol (1 mmol) with 70% TBHP (6 or 10 equiv.) is reacted with stirring at 100°C for 24 hours. Upon completion of the reaction, the reaction mixture was quenched with saturated sodium thiosulfate solution (5 mL) and subsequently extracted with dichloromethane (3 x 10 mL). The combined dichloromethane extracts were dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by rapid column chromatography on silica gel, and petroleum ether (PE) or mixed solvent of petroleum ether/ethyl acetate (PE/EtOAc) was selected as eluent to finally obtain 5-bromoindanone.

[1] TUTAR A, YILMAZ M, ERENLER R. Bromination of 4-bromoindanone and 5-bromoindanone[C]. 2013. DOI:10.5151/CHEMPRO-15BMOS-BMOS2013\_20131023104831.