Chemical Properties
Colorless to light yellow liquid; fatty aroma with animal undertones.
Chemical Properties
Colourless or light yellow liquid.
Chemical Properties
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid
fumes when heated.
Definition
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).
Production Methods
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be
prepared from butyl oleate by a Bouveault–Blanc reduction with
sodium and butyl alcohol. An alternative method of manufacture is
by the hydrogenation of triolein in the presence of zinc chromite.
Brand name
Witcohol 85 (Witco); Witcohol 90 (Witco).
Aroma threshold values
Fatty-type, medium strength odor.
General Description
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.
Flammability and Explosibility
Nonflammable(100%)
Pharmaceutical Applications
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and has been used in transdermal delivery formulations.It has
been utilized in the development of biodegradable injectable
thermoplastic oligomers,and in aerosol formulations of insulin
and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may
exhibit antitumor properties via transmembrane permeation.
Safety Profile
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.
Safety
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritant material at
the levels employed as an excipient. However, contact dermatitis
due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in
animals with products containing 8% oleyl alcohol indicate a very
low toxicity. Formulations containing 8% or 20% oleyl alcohol
administered by gastric intubation, at doses up to 10 g/kg bodyweight,
caused no deaths and no toxic effects in rats.
storage
The bulk material should be stored in a well-closed container in a
cool, dry, place.
Purification Methods
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical
emulsions and ointments). Included in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
