Terpineol is a monoterpene alcohol that has been found in a variety of plants, including
Cannabis, and has diverse biological activities.
1 Terpineol contains the four isomers α-, β-, and γ-terpineol and terpinen-4-ol. α-Terpineol has antibacterial and antinociceptive properties.
2,3 It is active against a variety of periodontopathic and cariogenic bacteria, including strains of
P. gingivalis,
F. nucleatum, and
A. actinomycetemcomitans (MICs = 0.1-0.8 mg/ml), however, it is toxic to KB cells when used at a concentration of 0.8 mg/ml.
2 It also reduces mechanical hyperalgesia, as well as spontaneous and palpation-induced nociception, in a mouse model of cancer-induced pain beginning on day 5 when administered at a dose of 50 mg/kg per day.
3 Terpinen-4-ol has anticonvulsant properties, inhibiting pentylenetetrazol-induced seizures in mice when used at doses ranging from 50 to 200 mg/kg.
4 α-Terpineol and terpinen-4-ol also have anti-inflammatory properties, reducing LPS-induced production of IL-1β, IL-6, and IL-10, but not TNF-α, in U937 cells.
5 This product is a mixture of α-, β-, and γ-terpineol.
